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Related Experiment Video

Updated: Jun 16, 2026

Direct and Indirect Culture Methods for Studying Biodegradable Implant Materials In Vitro

Direct and Indirect Culture Methods for Studying Biodegradable Implant Materials In Vitro

Published on: April 15, 2022

Biodegradable Zn-Based Implants: Progress, Challenges, and Pathways toward Clinical Translation.

Panfeng Zhao^1,2, Zhengquan Wang², Hui Yang²

¹School of Materials Science and Engineering, Northeastern University, Shenyang, China.

Advanced Science (Weinheim, Baden-Wurttemberg, Germany)

|June 15, 2026

Summary

This summary is machine-generated.

Biodegradable zinc (Zn) implants show promise for medical use. Research focuses on optimizing Zn implants through alloying and coatings to overcome challenges in corrosion, antibacterial properties, and biocompatibility for clinical success.

Keywords:

Zn‐based biodegradable implants antibacterial activity biocompatibility clinical translation corrosion control

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Last Updated: Jun 16, 2026

Direct and Indirect Culture Methods for Studying Biodegradable Implant Materials In Vitro

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Published on: April 15, 2022

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Multi-Scale Modification of Metallic Implants With Pore Gradients, Polyelectrolytes and Their Indirect Monitoring In vivo

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Published on: July 1, 2013

Area of Science:

Biomaterials Science
Medical Device Engineering
Metallurgical Engineering

Background:

Biodegradable zinc (Zn)-based implants are emerging as a promising class of biomaterials.
Their favorable biocompatibility and tunable degradation rates offer advantages over traditional materials.
Zn's physiological roles are critical for its potential in medical applications.

Purpose of the Study:

To review recent advancements in Zn-based implant technology.
To highlight strategies for overcoming challenges in corrosion, antibacterial efficacy, and biocompatibility.
To discuss evaluation systems, preclinical studies, clinical trials, and regulatory aspects.

Main Methods:

Literature review of recent progress in Zn-based implants.
Analysis of innovative strategies: alloying (Zn-Mg, Zn-Mn, Zn-Li), surface modifications, and functional coatings.
Overview of in vitro/in vivo degradation evaluation, preclinical studies, clinical trials, and regulatory standards.

Main Results:

Zn-based implants offer tunable degradation and good biocompatibility.
Alloying, surface modifications, and coatings are effective strategies to optimize performance.
Progress in evaluation systems and preclinical studies is evident, with some clinical trials underway.

Conclusions:

Zn-based implants represent a significant advancement in biodegradable medical devices.
Addressing bottlenecks in corrosion, antibacterial properties, and biocompatibility is crucial for clinical translation.
Standardized evaluation and rational design are key for next-generation Zn implants.