Mirror-image Bilateral Complete and Incomplete Cleft Lip and Alveolus in Monozygotic Twins: A Case Report
Sebastian Köppert1, Paul Metz1, Henning Hanken1
1Department of Oral and Maxillofacial Surgery, Asklepios Klinik Nord - Heidberg, Hamburg, Germany.
Summary
Mirror-image cleft lip and/or palate (CL/P) is a rare congenital malformation. This case report details a rare instance of mirror-image bilateral CL/P in monozygotic twins.
Area of Science:
- Oral and Maxillofacial Surgery
- Medical Genetics
- Developmental Biology
Background:
- Cleft lip and/or palate (CL/P) are common congenital malformations.
- Monzygotic twins show higher concordance rates for CL/P.
- Mirror-image cleft formations are exceptionally rare phenotypes.
Purpose of the Study:
- To report a rare case of mirror-image bilateral cleft lip and alveolus in monozygotic twins.
- To contribute to the limited literature on this specific CL/P phenotype.
Main Methods:
- Case report.
- Description of a female pair of monozygotic twins.
- Documentation of bilateral complete and incomplete cleft lip and alveolus.
Main Results:
- The case report details a rare occurrence of mirror-image bilateral complete and incomplete cleft lip and alveolus.
- This presentation is a very rare phenotype within CL/P subtypes.
Conclusions:
- Mirror-image bilateral CL/P, while rare, can occur in monozygotic twins.
- Further research and case documentation are needed for this rare congenital malformation.