Clinical and Laboratory Indicators Associated with Cirrhosis Severity

Area of Science:

• Hepatology
• Clinical Medicine
• Biochemistry

Background:

• Cirrhosis severity assessment is crucial for patient management.
• Existing clinical and laboratory indicators require further evaluation for accuracy.

Purpose of the Study:

• To identify clinical and laboratory indicators associated with varying cirrhosis severity.
• To support more accurate clinical assessment and stratification of cirrhosis patients.

Main Methods:

• Retrospective analysis of 180 cirrhosis patients (Child-Pugh A, B, C).
• Stratification based on Child-Pugh classification.
• Statistical analysis to identify associations between variables and cirrhosis severity.

Main Results:

• Fever and spontaneous bacterial peritonitis were more frequent in advanced cirrhosis.
• Significant associations found between cirrhosis severity and serum calcium (Ca²⁺), white blood cell count (WBC), platelet count (PLT), C-reactive protein (CRP), hemoglobin (Hb), fibrinogen (FIB), total bile acids (TBA), apolipoprotein A1 (APOA1), direct bilirubin (DBIL), cholinesterase (CHE), cystatin C (CYSC), and bicarbonate (HCO3-).
• TBA and DBIL positively correlated with severity; FIB, APOA1, CHE, HCO3- negatively correlated.

Conclusions:

• Fever, spontaneous bacterial peritonitis, CRP, PLT, FIB, TBA, Ca²⁺, APOA1, CHE, CYSC, and HCO3- are relevant indicators for cirrhosis severity.
• These indicators can aid in improved clinical stratification.
• Recognition of these markers can guide management decisions for cirrhosis patients.