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A case Report of Pulmonary Langerhans Cell Histiocytosis in a Child
Background:
Langerhans cell histiocytosis (LCH) is a clonal neoplastic disorder characterized by the aberrant proliferation of CD1a+/CD207+dendritic cells that infiltrate tissues and organs, resulting in organ dysfunction.
Methods:
This case report describes a 2-year-old boy who presented with abdominal pain and fever. The etiology was ultimately confirmed through clinical symptoms, imaging studies, pulmonary histopathological examination, and genetic testing.
Results:
The final diagnosis was pediatric pulmonary Langerhans cell histiocytosis (PLCH).
Conclusions:
Although pulmonary involvement is not classified as a high-risk in consensus guidelines, PLCH requires diagnostic consideration in children presenting with persistent respiratory symptoms and recurrent fever.