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Unraveling the complex web of acute kidney injury: pathways, biomarkers, and future directions

Chengxi Zha1, Yaya Qi2, De Yang1

  • 1Gansu Provincial Hospital of Traditional Chinese Medicine, Clinical Laboratory, Lanzhou, China.

Jornal Brasileiro De Nefrologia
|June 15, 2026
PubMed

Insights

Acute kidney injury (AKI) research is vital for understanding its causes and developing treatments. This review explores AKI signaling pathways, diagnostics, and novel therapies for better patient outcomes.

Area of Science:

  • Nephrology
  • Molecular Biology
  • Pathophysiology

Background:

  • Acute kidney injury (AKI) is a global health concern with high incidence and mortality.
  • Understanding AKI pathogenesis is critical for improving patient care and developing new treatments.

Purpose of the Study:

  • To comprehensively review AKI signaling pathways, from pathophysiology to therapeutic strategies.
  • To explore advancements in biomarkers, drug development, and gene editing for AKI.
  • To discuss current controversies and future research directions in AKI signaling.

Main Methods:

  • Literature review of AKI pathophysiological mechanisms, apoptosis, and inflammation signaling pathways.
  • Analysis of clinical signaling pathways, epidemiology, diagnostics, and therapeutic strategies.
  • Examination of novel biomarkers, drug development, and gene editing technologies in AKI.

Main Results:

  • Detailed examination of AKI signaling pathways involved in pathogenesis.
  • Analysis of clinical applications including diagnostics and therapeutics.
  • Overview of emerging technologies and their potential impact on AKI treatment.

Conclusions:

  • Signaling pathway research is essential for advancing AKI understanding and treatment.
  • Novel biomarkers and gene editing hold promise for personalized AKI therapies.
  • Continued research into AKI signaling pathways is crucial for addressing challenges and seizing opportunities.

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