Related Experiment Video
Updated: Jun 16, 2026

Studies of Chaperone-Cochaperone Interactions using Homogenous Bead-Based Assay
Published on: July 21, 2021
Epigallocatechin-3-gallate (EGCG) as a molecular chaperone and network rebalancer in neurodegenerative diseases
Husni Farah1, Media Hamed Ahmed2, Shaker Al-Hasnaawei3,4
1Faculty of Allied Medical Sciences, Hourani Center for Applied Scientific Research, Al-Ahliyya Amman University, Amman, Jordan. h.farah@ammanu.edu.jo.
Abstract:
Epigallocatechin-3-gallate (EGCG), the primary catechin in green tea, has emerged as a paradigmatic multi-target molecule capable of modulating convergent molecular processes underlying neurodegenerative diseases such as Alzheimer's and Parkinson's. Through its dual action as a molecular chaperone and signalling rebalancer, EGCG redefines the concept of natural compounds as network regulators rather than isolated antioxidants. This review integrates mechanistic, biochemical, and translational insights to elucidate how EGCG influences protein aggregation, neuroinflammation, redox signalling, and synaptic resilience, and proposes future molecular engineering strategies to enhance its therapeutic potential.
Related Concept Videos
Neural Regulation
Molecular Chaperones and Protein Folding
The...
Molecular Chaperones and Protein Folding
The...
Protein Folding Quality Check in the RER
Cognitive Enhancers: Cholinesterase Inhibitors and NMDA Receptor Antagonists