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Measuring Frailty in HIV-infected Individuals. Identification of Frail Patients is the First Step to Amelioration and Reversal of Frailty
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Published on: July 24, 2013

External Validation of a Community Pharmacy-Based Screening Tool for Frailty That Uses Routinely Collected Data.

Marie Carrein1,2, Johan Van der Heyden3, Els Mehuys4

  • 1Pharmaceutical Care Unit, Faculty of Pharmaceutical Sciences, Ghent University, Ottergemsesteenweg 460, 9000, Ghent, Belgium. marie.carrein@ugent.be.

Drugs & Aging
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Summary
This summary is machine-generated.

A new frailty screening tool accurately identifies older adults at risk for medication harm in community pharmacies. This validation confirms its reliability for early detection and intervention in frail populations.

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Published on: October 6, 2016

Area of Science:

  • Gerontology
  • Pharmaceutical Sciences
  • Public Health

Background:

  • Frailty in older adults significantly elevates the risk of medication-related harm.
  • Early identification of drug-related problems during medication reviews is crucial.
  • A novel screening tool utilizing electronic pharmacy data offers a practical solution for community pharmacists.

Purpose of the Study:

  • To externally validate a new frailty screening tool designed for community pharmacy settings.
  • To assess the tool's performance in identifying frail older adults using real-world data.

Main Methods:

  • External validation using data from the HISLink project, linking national health interview survey data with health insurance claims.
  • Frailty status determined using the SHARE-FI instrument for performance evaluation.
  • Logistic recalibration applied to adjust for cohort differences; subgroup sensitivity analysis conducted.

Main Results:

  • The screening tool identified 31.6% of 2191 participants (mean age 74.4 years) as frail.
  • Good discrimination observed with an AUC of 0.77; sensitivity 63.9%, specificity 76.8%.
  • Calibration improved post-recalibration (Brier score 0.13); performance in polypharmacy subgroup noted (AUC 0.72).

Conclusions:

  • The frailty screening tool is a valid and reliable method for identifying at-risk older adults in community pharmacies.
  • External validation using HISLink project data confirms the tool's previously established good performance.
  • The tool supports proactive identification of frail individuals, enabling timely interventions to prevent medication-related harm.