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Related Experiment Video

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Catheter Ablation in Combination With Left Atrial Appendage Closure for Atrial Fibrillation

Catheter Ablation in Combination With Left Atrial Appendage Closure for Atrial Fibrillation

Published on: February 26, 2013

Health Status Changes and Long-Term Clinical Outcomes in Patients With Atrial Fibrillation.

Takanori Ohata¹, Nobuhiro Ikemura^1,2,3, Shun Kohsaka¹

¹Department of Cardiology, Keio University School of Medicine, Tokyo, Japan.

JAMA Network Open

|June 15, 2026

Summary

Improving patient health status in atrial fibrillation (AF) is linked to better clinical outcomes. Enhanced AF management focusing on quality of life may reduce adverse events.

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Area of Science:

Cardiology
Patient-Reported Outcomes
Clinical Epidemiology

Background:

Improving health status is a primary goal in managing atrial fibrillation (AF).
The association between enhanced patient-reported health status and subsequent clinical outcomes in AF is not well understood.

Purpose of the Study:

To evaluate the association between changes in patient-reported health status and long-term adverse clinical outcomes in patients with AF.

Main Methods:

A prospective multicenter cohort study in Japan involving 2744 patients with AF.
Utilized the Atrial Fibrillation Effect on Quality of Life (AF PROM) questionnaire at baseline and 1-year follow-up.
Assessed composite outcomes of all-cause death, heart failure hospitalization, and stroke/TIA over 4 years post-1-year assessment using regression models.

Main Results:

Over 51% of patients experienced improved health status (≥5-point increase in AF PROM score) at 1 year.
Greater improvement in AF PROM scores was associated with a significantly lower risk of adverse clinical outcomes (HR 0.93 per 5-point increase, P<.001).
Adjusted analyses confirmed the association between improved health status and reduced adverse events.

Conclusions:

Improvements in patient-reported health status, measured by the AF PROM, are associated with a lower risk of long-term adverse clinical outcomes in patients with AF.
Patient-reported outcome measures (PROMs) possess prognostic value in AF management.
Monitoring and improving patient health status should be a key focus in AF care.