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Updated: Jun 16, 2026

Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein
07:29

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Published on: October 12, 2017

Expression of Apolipoprotein L1 Risk Variants at the Plasma Membrane and Haplotype-Dependent Cytotoxicity

Oyindamola Christiana Adebayo1,2, Ilhem Dallali3,4,5, Sara Kerselaers4,5

  • 1Department of Cardiovascular Sciences, Center for Molecular and Vascular Biology, KU Leuven, Leuven, Belgium.

Journal of the American Society of Nephrology : JASN
|June 15, 2026
PubMed
Summary

Apolipoprotein L1 (APOL1) risk variants form calcium (Ca2+) pores in cell membranes, increasing cell damage. This gain-of-function mechanism explains APOL1-associated kidney disease and can be blocked by specific variants or inhibitors.

Keywords:
apolipoprotein L1 (APOL1)

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