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Ti3C2Tx MXene Nanosheets: Bridging High-Performance Energy Storage and Comprehensive In Vivo Biocompatibility
Tanveer Ali1,2, Ali Shan3, Mirza Mahmood Baig4
1Institute of Integrative Medicine, Dalian Medical University, Dalian 0411, China.
ACS Applied Materials & Interfaces
|June 15, 2026
Summary
This study presents flexible, stable asymmetric supercapacitors made from MXene nanosheets for bioelectronic devices. These MXene nanosheets also show promising biocompatibility and antioxidant properties in vivo.
Area of Science:
- Materials Science
- Electrochemistry
- Biomedical Engineering
Background:
- Advancements in implantable bioelectronic devices necessitate biocompatible energy sources with long-term stability.
- Existing energy sources often lack the required electrochemical and mechanical stability for long-term implantation.
Purpose of the Study:
- To fabricate and characterize a flexible asymmetric supercapacitor using Ti3C2Tx MXene nanosheets.
- To evaluate the in vivo safety profile and antioxidant potential of Ti3C2Tx MXene nanosheets for biomedical applications.
Main Methods:
- Fabrication of a flexible asymmetric supercapacitor (MXene//AC) using 2D Ti3C2Tx MXene nanosheets.
- Electrochemical performance testing, including capacitance, energy density, power density, and cycle life.
- Density Functional Theory (DFT) analysis to understand charge storage mechanisms.
- In vivo toxicity evaluations (acute dermal, subchronic oral, and intraperitoneal) in Sprague-Dawley rats.
- Assessment of antioxidant activity using DPPH assay.
Main Results:
- The MXene//AC supercapacitor exhibited high areal capacitance (66.43 mF cm-2), energy density (13.2 Wh kg-1), and power density (2300 W kg-1).
- The device retained 95% capacitance after 5000 cycles and showed excellent mechanical stability under bending.
- DFT analysis indicated synergistic effects for rapid electron transport and pseudocapacitive charge storage.
- In vivo studies revealed no significant toxicity or adverse effects in rats at tested doses.
- MXene nanosheets demonstrated dose-dependent antioxidant activity.
Conclusions:
- Ti3C2Tx MXene nanosheets are suitable for developing high-performance, flexible, and stable asymmetric supercapacitors.
- MXene nanosheets possess favorable in vivo biocompatibility and antioxidant properties, making them promising for bioelectronic applications.
- These findings support the potential of MXene-based materials as next-generation biocompatible energy storage devices for implantable systems.
