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Extracellular CIRP aggravates cardiac dysfunction via the TLR4/MD2-NLRP3 axis during venoarterial ECMO

Huizhen Li1, Junjie Shao2, Jian Li3

  • 1Department of Cardiac Surgery, Lanzhou University Second Hospital, Lanzhou 730030, China; The Second Clinical Medical College of Lanzhou University, Lanzhou University, Lanzhou 730030, Gansu, China; Cuiying Biomedical Research Center, Lanzhou University Second Hospital, Lanzhou University, Lanzhou, China.

International Immunopharmacology
|June 15, 2026
PubMed
Abstract

Keywords:
Cardiogenic shockCold-inducible RNA-binding proteinMyocardial injuryNLRP3Veno-arterial extracorporeal membrane oxygenation

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