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Related Concept Videos

Sleep Apnea01:21

Sleep Apnea

Sleep apnea is a condition where breathing stops intermittently during sleep, often leading to significant health issues. Each episode can last from 10 to 20 seconds or more and is frequently accompanied by a brief arousal from sleep. This disturbance, largely unnoticed by the individual, can lead to severe daytime fatigue. Commonly, individuals seek help after being informed by their partners about loud snoring and noticeable breathing pauses during sleep.
The condition is more prevalent among...
Heart Failure VI: Adjunct Therapies01:22

Heart Failure VI: Adjunct Therapies

Additional therapies for treating patients with heart failure (HF) may include procedural interventions, supplemental oxygen, the management of sleep disorders, and nutritional therapy.Procedural InterventionsImplantable Cardioverter-Defibrillator: For patients at risk of life-threatening arrhythmias due to severe left ventricular dysfunction, an Implantable Cardioverter-Defibrillator (ICD) can detect and terminate these arrhythmias, preventing sudden cardiac death and improving survival rates.
Acute Respiratory Failure-IV01:23

Acute Respiratory Failure-IV

Respiratory failure can manifest suddenly or gradually, characterized by a rapid decline in PaO2 and a rapid rise in PaCO2. This situation indicates a severe respiratory problem that may quickly become a life-threatening emergency. One of the early signs of hypoxemic Acute Respiratory Failure (ARF) is a change in mental status due to the brain's sensitivity to oxygen levels and changes in acid-base balance. Symptoms such as restlessness, confusion, and agitation suggest inadequate oxygen...

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Related Experiment Video

Updated: Jun 17, 2026

Drug-Induced Sleep Endoscopy (DISE) with Target Controlled Infusion (TCI) and Bispectral Analysis in Obstructive Sleep Apnea
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Published on: December 6, 2016

Mitochondrial dysfunction in patients with severe obstructive sleep apnea.

Ti-Ni Huang1, Yao-Pang Chung2, Rong-Jaan Lin3

  • 1Ph.D Program for Aging, China Medical University, Taichung, Taiwan.

Sleep Medicine
|June 15, 2026
PubMed
Summary
This summary is machine-generated.

Severe obstructive sleep apnea (OSA) is linked to lower mitochondrial DNA copy number (mtDNA-CN), a marker of mitochondrial health. This suggests OSA may contribute to cellular aging and metabolic issues.

Keywords:
HbA1cMitochondrial DNA copy number (mtDNA-CN)Obstructive sleep apnea (OSA)

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Last Updated: Jun 17, 2026

Drug-Induced Sleep Endoscopy (DISE) with Target Controlled Infusion (TCI) and Bispectral Analysis in Obstructive Sleep Apnea
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Area of Science:

  • Mitochondrial biology
  • Sleep medicine
  • Biomarker research

Background:

  • Obstructive sleep apnea (OSA) is a common disorder linked to intermittent hypoxia and oxidative stress.
  • These factors can impair mitochondrial function and accelerate cellular aging.
  • Mitochondrial DNA copy number (mtDNA-CN) serves as a biomarker for mitochondrial health.

Purpose of the Study:

  • To investigate differences in mtDNA-CN between individuals with severe OSA and those without.
  • To explore the association between severe OSA and mtDNA-CN levels.

Main Methods:

  • A cross-sectional study involving 97 participants at Taichung Hospital, Taiwan.
  • Overnight polysomnography and blood tests were conducted.
  • Leukocyte DNA was extracted to measure mtDNA-CN.

Main Results:

  • Severe OSA was associated with significantly lower mtDNA-CN compared to non-severe OSA.
  • Individuals with severe OSA also showed higher blood glucose, HbA1c, AST, ALT, and creatinine levels.
  • A lower estimated glomerular filtration rate was observed in severe OSA patients.

Conclusions:

  • Severe OSA is significantly associated with reduced mtDNA-CN, even after adjusting for confounders.
  • Findings suggest a connection between OSA, mitochondrial dysfunction, and metabolic alterations.
  • The cross-sectional design prevents establishing causal relationships.