Atmospheric pollutants and airborne bacteria: adaptation mechanisms, virulence modulation, and public health...

Outdoor air pollution is a major public health issue. Many studies correlate ambient air pollution with acute and chronic pulmonary disease. However, its interactions with airborne bacteria remain insufficiently characterized. In particular, the mechanisms linking pollutants to microbial adaptation and pathogenicity are not clearly established. An increasing body of evidence shows that airborne bacteria respond actively to atmospheric pollutants. These responses affect their survival, behavior, and functional traits. However, a comprehensive synthesis of pollutant-driven microbial adaptation and its implications for virulence and public health, is still lacking. This review synthesizes current knowledge on the interactions between atmospheric pollutants and airborne bacteria within an integrative mechanistic and One Health framework. The nature and sources of major atmospheric pollutants are first outlined. The mechanisms by which these pollutants induce oxidative and nitrosative stress in bacteria are then analyzed, with a focus on the generation of reactive oxygen and nitrogen species and their cellular impacts. Bacterial adaptive responses to these stresses are subsequently discussed. These include antioxidant defenses, membrane remodeling, biofilm formation, and horizontal gene transfer. The potential contribution of these processes to bacterial persistence, virulence-associated traits, and antibiotic resistance is discussed. The implications for human and environmental health are then addressed. Particular attention is given to respiratory infections, the enrichment of airborne resistomes, and the emergence of opportunistic taxa in polluted environments. Finally, future research directions including key knowledge gaps are summarized.