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Updated: Jun 17, 2026

Investigating Long-term Synaptic Plasticity in Interlamellar Hippocampus CA1 by Electrophysiological Field Recording
Published on: August 11, 2019
Rapid strengthening and reversal of hippocampal-neocortical interplay mediates human memory formation
Lukang Wang1, Qingtian Duan2, Jianping Song3
1Department of Neurosurgery, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, China; Brain Research Center and State Key Laboratory of Trauma and Chemical Poisoning, Third Military Medical University, Chongqing 400038, China.
Abstract:
Classical theories of systems consolidation highlight the importance of hippocampal-neocortical interplay for long-term memory formation. However, how this interaction evolves during multiple days of learning remains unclear. Using day-by-day multisite intracranial electrophysiology, we examined human subjects performing a repeated picture-learning task. From day 1 today 2, the ripple rates during picture learning and free recall significantly increased in the hippocampus and neocortex, which correlated with behavioral memory performance. These enhancements persisted throughout the remaining task days. Notably, from day 2 onward, the ripple coupling between the neocortex and hippocampus not only strengthened, but the temporal sequence of these coupled ripples also reversed-from hippocampus leading to neocortex leading. This rapid strengthening and reversal of hippocampal-neocortical information flow on the second day represents a key signature of human memory formation.
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