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Delivery Pathways to the Lysosome

Delivery Pathways to the Lysosome

Eukaryotic cells use different mechanisms to eliminate toxic waste obsolete and worn-out substances. Lysosomes play a pivotal role in this, and hence, these substances are carried to the lysosome from other parts of the cell and extracellular space through different pathways. The most elaborately studied pathways to the lysosome are the endocytic pathways.
Endocytosis
In endocytosis, the cell membrane takes up macromolecules and particles from the surrounding medium. Clathrin-mediated...

Modified-Release Drug Delivery Systems: Rate-Programmed I

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Rate-programmed drug delivery systems (DDS) are designed to release drugs at specific, controlled rates to maintain consistent therapeutic levels. These systems are categorized based on their release mechanisms, including dissolution-controlled DDS, diffusion-controlled DDS, and combined dissolution-diffusion-controlled DDS.In dissolution-controlled DDS, the release rate depends on the slow dissolution of the drug itself or the surrounding matrix. Drugs with inherently slow dissolution rates,...

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Updated: Jun 17, 2026

Microfluidic Production of Lysolipid-Containing Temperature-Sensitive Liposomes

Microfluidic Production of Lysolipid-Containing Temperature-Sensitive Liposomes

Published on: March 3, 2020

Lysing with Light: Trackable On Demand Molecular Delivery.

Kavyasree Manal¹, Vasudev Deepa Sreekumar¹, Lakshmy Kannadi Valloli¹

¹Center for Photochemical Sciences and Department of Chemistry, Bowling Green State University, Bowling Green, Ohio 43403, United States.

Journal of the American Chemical Society

|June 15, 2026

Summary

This summary is machine-generated.

A novel enaminone reactivity enables a light-initiated lysing system. This system allows on-demand cargo release and generates a fluorescent reporter, tunable across UV and visible light wavelengths.

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Area of Science:

Photochemistry
Organic Chemistry
Biotechnology

Background:

Controlled release systems are crucial for drug delivery and diagnostics.
Existing light-initiated systems often lack tunability or dual functionality.

Purpose of the Study:

To introduce a novel enaminone-based light-initiated lysing system.
To demonstrate tunable wavelength responsiveness for cargo release and reporter generation.

Main Methods:

Exploration of novel enaminone reactivity under UV and visible light.
Development of a system for on-demand cargo release.
Integration of in situ fluorescent reporter generation.

Main Results:

Disclosed a previously unknown reactivity of enaminone.
Demonstrated wavelength tunability across UV and visible light spectra.
Achieved simultaneous cargo release and fluorescent reporter generation.

Conclusions:

The novel enaminone reactivity provides a versatile platform for light-controlled molecular systems.
This system offers on-demand cargo release and integrated fluorescent reporting.
The tunable nature allows for diverse applications in chemical biology and materials science.