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Spatial Transcriptomics Identifies Cytotoxic and Fibrotic Immune-Stromal Niches in Morphea and Eosinophilic Fasciitis

William J Crisler1, Kseniia S Anufrieva2, Maureen Whittelsey1

  • 1Department of Dermatology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

The Journal of Investigative Dermatology
|June 15, 2026
PubMed
Abstract

No abstract available in PubMed .

Keywords:
Morpheacytotoxic T cellseosinophilic fasciitisfibrosisspatial transcriptomics

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Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...