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Related Concept Videos

Infertility in Males01:23

Infertility in Males

Male infertility affects millions of couples worldwide, arising from various factors that impact different stages of the reproductive process. An endocrine imbalance resulting from conditions like hypogonadism, Klinefelter syndrome, or pituitary disorders can disrupt hormone levels and reduce sperm production. Testicular defects, such as tumors, cryptorchidism, atrophic testes, abnormal sperm morphology, and low sperm count or motility, may arise due to genetic factors, structural...

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Related Experiment Video

Updated: Jun 17, 2026

Vessel-Sparing Microsurgical Longitudinal Intussusception Vasoepididymostomy to Treat Epididymal Obstructive Azoospermia
06:28

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Published on: May 27, 2022

Non-Obstructive Azoospermia: Micro-TESE Combined with Advanced Sperm Processing for Enhanced Assisted Reproductive

Pauline Venot1, Benoît Mesnard2, Aurélie Schirmann1

  • 1Department of Urology, Hospital Foch, 40 rue Worth, 92150 Suresnes, France.

The French Journal of Urology
|June 15, 2026
PubMed
Summary
This summary is machine-generated.

Microdissection testicular sperm extraction (mTESE) combined with advanced techniques achieved live birth or ongoing pregnancy in 27.3% of non-obstructive azoospermia (NOA) cases. This study evaluated reproductive outcomes, demonstrating mTESE

Keywords:
AzoospermiaAzoospermieCryopreservationCryopréservationExtraction de spermatozoïdes testiculaire (TESE)GrossessesInjection intracytoplasmique de spermatozoïdes (ICSI)Intracytoplasmic Sperm Injection (ICSI)Live BirthNaissances vivantesPregnancyTesticular Sperm Extraction (TESE)

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Last Updated: Jun 17, 2026

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Area of Science:

  • Reproductive Medicine
  • Andrology
  • Infertility Research

Background:

  • Non-obstructive azoospermia (NOA) affects 10% of male infertility cases.
  • Microdissection testicular sperm extraction (mTESE) is the gold standard for sperm retrieval in NOA.
  • Optimizing assisted reproductive technology (ART) pathways is crucial for live birth outcomes.

Purpose of the Study:

  • To evaluate live birth and ongoing pregnancy rates (LBR) following mTESE in NOA patients.
  • To assess the impact of advanced sperm preparation techniques on ART outcomes.
  • To identify risk factors associated with unsuccessful sperm retrieval in NOA.

Main Methods:

  • Retrospective study of 55 NOA patients undergoing mTESE (July 2019 - March 2023).
  • Primary outcome: LBR; Secondary outcome: Sperm Retrieval Rate (SRR).
  • Univariate analyses to identify risk factors for unsuccessful sperm retrieval.

Main Results:

  • SRR was 47.3% (53.2% excluding Klinefelter patients).
  • LBR and ongoing pregnancies achieved in 27.3% of couples.
  • Karyotype abnormalities, elevated FSH, and familial infertility correlated with unsuccessful sperm retrieval.

Conclusions:

  • mTESE combined with advanced techniques resulted in a 27.3% LBR/ongoing pregnancy rate in NOA.
  • Successful sperm retrieval and subsequent live birth are achievable without donor sperm.
  • Identifying risk factors can help counsel patients undergoing mTESE for NOA.