Related Experiment Videos

Atypical multisystem inflammatory syndrome in children presenting with 1-month persistent fever in a 17-month-old: A

Mohammad Noor Katranjy1, Ahmad Alabdlilrazzak1, Mohamad Alharbi1

  • 1Faculty of Medicine, Hama University, Syria.

The Journal of International Medical Research
|June 15, 2026
PubMed

Insights

Multisystem Inflammatory Syndrome in Children (MIS-C) is a severe complication of COVID-19 in youth. This case report details a toddler

Area of Science:

  • Pediatrics
  • Infectious Diseases
  • Immunology

Background:

  • Multisystem Inflammatory Syndrome in Children (MIS-C) is a rare but serious complication of coronavirus disease 2019 (COVID-19).
  • MIS-C affects individuals under 19, presenting with diverse and potentially severe clinical manifestations.
  • Management of MIS-C is complex due to varied presentations and treatment responses.

Purpose of the Study:

  • To describe a case of MIS-C in a toddler with prolonged fever and gastrointestinal symptoms.
  • To highlight the diagnostic challenges and successful treatment of MIS-C.
  • To contribute to the understanding of MIS-C presentation in young children without prior documented SARS-CoV-2 infection.

Main Methods:

  • Case report of a toddler with a 30-day relapsing fever, gastrointestinal symptoms, and rash.
  • Clinical and laboratory investigations were performed.
  • Treatment involved intravenous immunoglobulin and corticosteroids.

Main Results:

  • The patient, a toddler with no prior documented severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, presented with prolonged fever, gastrointestinal issues, and rash.
  • Diagnosis of MIS-C was confirmed after extensive evaluation.
  • The child showed a positive response to treatment with intravenous immunoglobulin and corticosteroids.

Conclusions:

  • MIS-C can occur in young children even without a history of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.
  • Early diagnosis and prompt treatment with immunomodulatory therapies are crucial for favorable outcomes in MIS-C.
  • This case underscores the importance of considering MIS-C in pediatric patients with unexplained prolonged fever and systemic inflammation.

Keywords:
Case reportcoronavirus disease 2019fevermultisystem inflammatory syndrome in childrenpediatrics

Related Concept Videos

Patterns of Fever01:26

Patterns of Fever

Before understanding the types and patterns of fever, it is essential to know its phases.
Rocky Mountain Spotted Fever01:26

Rocky Mountain Spotted Fever

Rocky Mountain Spotted Fever (RMSF) is a severe tick-borne illness caused by Rickettsia rickettsii, a Gram-negative, coccobacillary bacterium. This pathogen is an obligate intracellular parasite, requiring a host cell for replication. Transmission occurs through the bite of an infected tick. In the United States, the most important vectors are Dermacentor variabilis (American dog tick) and Dermacentor andersoni (Rocky Mountain wood tick), though other tick species may also serve as vectors.
Myocarditis II: Clinical Features and Diagnostic Tests01:27

Myocarditis II: Clinical Features and Diagnostic Tests

Myocarditis is an inflammation of the heart muscle. The symptoms vary widely, encompassing asymptomatic presentations to severe, acute manifestations.Clinical PresentationAsymptomatic cases: In some instances, myocarditis may be asymptomatic, with the infection resolving without intervention. These cases often go undetected unless discovered incidentally through diagnostic imaging or tests conducted for other reasons.General Early Symptoms: Early symptoms of myocarditis are non-specific and can...
Atypical Pneumonia01:14

Atypical Pneumonia

Atypical pneumonia, often caused by Mycoplasma pneumoniae, is a form of pulmonary infection that differs from the classical presentation of bacterial pneumonia in both its cause and clinical symptoms. Mycoplasma pneumoniae is a pleomorphic bacterium notable for its lack of a rigid cell wall. This structural characteristic imparts resistance to beta-lactam antibiotics and significantly influences the bacterium’s behavior within the human host.Other pathogens responsible for the disease include...
Types of Fever01:25

Types of Fever

Fever can be triggered by several factors, including infections, nervous system disorders, certain cancers, blood diseases like leukemia, embolism, thrombosis, heatstroke, dehydration, surgical trauma, crushing injuries, and allergic reactions.
Here are the different types of fever:
Increased Body Temperature01:25

Increased Body Temperature

A body temperature above  38°C  (100.4 °F) is known as fever or pyrexia, and a person with fever is termed 'febrile.' Typically, the hypothalamus, a part of the brain that acts as the body's thermostat, regulates body temperature through a thermoregulatory setpoint. It receives signals from cold and warm thermal receptors throughout the body and adjusts the body's temperature accordingly. Fever occurs when this hypothalamic setpoint is altered, usually in response to an infection or illness.