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[Treatment options for marginal zone lymphoma]

Q Jiang1, X Wang2, X X Xiang1

  • 1Medical Center of Hematology, the Second Affiliated Hospital (Xinqiao Hospital) of Army Medical University, Chongqing 400037, China.

Zhonghua Yi Xue Za Zhi
|June 15, 2026
PubMed

Marginal zone lymphoma (MZL) is a group of indolent B-cell lymphomas with high biological and clinical heterogeneity, including mucosa-associated lymphoid tissue, nodal, and splenic MZL. Despite diverse first-line treatment options, significant differences exist between guidelines and clinical practices, lacking a unified and standardized treatment pathway.Therefore, this article elaborates on the assessment of treatment indications of MZL, the initial therapies for different MZL subtypes, and summarizes the treatment for relapsed/refractory MZL, the selection of maintenance therapy, and management of treatment-related complications, aiming to offer evidence-based guidance and individualized therapeutic decision-making in clinical practice.

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