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Monocyte dipeptidyl peptidase 4 activity is associated with urinary albumin excretion in type 2 diabetes

Hideyuki Okuma1, Takahiro Tsutsumi2, Kyoichiro Tsuchiya2

  • 1Department of Diabetes and Endocrinology, Nerima Hikarigaoka Hospital, Tokyo, Japan.

Journal of Diabetes Investigation
|June 16, 2026
PubMed
Abstract

Insights

Monocyte dipeptidyl peptidase 4 (DPP4) activity correlates with urinary albumin excretion in type 2 diabetes mellitus (T2DM) patients. This suggests monocytes link DPP4 to diabetic kidney disease (DKD) pathogenesis.

Area of Science:

  • Nephrology
  • Immunology
  • Endocrinology

Background:

  • Diabetic kidney disease (DKD) pathogenesis may involve pro-inflammatory genes in monocytes and dipeptidyl peptidase 4 (DPP4).
  • The specific association between monocyte DPP4 and renal parameters in DKD remains unclear.

Purpose of the Study:

  • To investigate the relationship between monocyte DPP4 expression and activity with renal parameters in patients with type 2 diabetes mellitus (T2DM).

Main Methods:

  • A cross-sectional study compared 64 T2DM patients and 50 healthy controls.
  • Monocytes were isolated, cultured, and stimulated (LPS). DPP4 and pro-inflammatory gene expression, and DPP4 activity were measured.
  • Renal parameters included urinary albumin-to-creatinine ratio (UACR) and estimated glomerular filtration rate (eGFR).

Main Results:

  • Elevated DPP4 gene expression and activity were observed in unstimulated monocytes of T2DM patients compared to controls.
  • In T2DM patients, LPS-stimulated monocyte DPP4 expression correlated positively with UACR and pro-inflammatory gene expression, but not eGFR.
  • Monocyte DPP4 activity (stimulated and unstimulated) positively correlated with UACR and pro-inflammatory gene expression, independent of eGFR.

Conclusions:

  • Monocyte DPP4 activity is linked to urinary albumin excretion in T2DM patients.
  • Monocytes may act as a cellular bridge connecting DPP4 and DKD development.
Keywords:
diabetic kidney diseasedipeptidyl peptidase 4monocyte

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