Related Experiment Video
Updated: Jun 17, 2026
10:03
Evaluation of Right Ventricular Function in Experimental Models of Pulmonary Arterial Hypertension
Published on: June 27, 2025
Relationship Between Triglyceride Glucose Index and Right Ventricular Dysfunction in Chronic Obstructive Pulmonary
Samah M Akab1, Heba Shoman1, Noran ElBazzar2
1Internal Medicine Department, Al-Azhar University, Cairo, Egypt.
Cardiovascular & Hematological Disorders Drug Targets
|June 16, 2026
Summary
The triglyceride glucose (TyG) index is linked to early right ventricular dysfunction (RVD) in chronic obstructive pulmonary disease (COPD) patients. This highlights the role of metabolic factors in COPD management.
Area of Science:
- Cardiology
- Pulmonology
- Metabolic Syndrome
Background:
- Chronic obstructive pulmonary disease (COPD) is a major health concern.
- Right ventricular dysfunction (RVD) is a common complication in COPD patients.
- The triglyceride glucose (TyG) index is a marker of insulin resistance.
Purpose of the Study:
- To investigate the association between the TyG index and early RVD in COPD patients.
- To identify predictors of RVD in COPD.
Main Methods:
- A study involving 100 COPD patients and 50 healthy controls.
- Echocardiography was used to assess RVD, with Tricuspid Annular Plane Systolic Excursion (TAPSE) < 17 indicating RVD.
- The TyG index was calculated for all participants.
Main Results:
- COPD patients had a significantly higher TyG index than controls (p <0.001).
- 33 COPD patients exhibited RVD.
- The TyG index was identified as an independent predictor of RVD in COPD patients (OR: 4.13, p=0.047).
Conclusions:
- The TyG index is associated with early RVD in COPD.
- Biometabolic factors, such as those reflected by the TyG index, are important in the pathogenesis and management of COPD.
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