Related Experiment Video
Updated: Jun 17, 2026

Synthesis of pH Dependent Pyrazole, Imidazole, and Isoindolone Dipyrrinone Fluorophores using a Claisen-Schmidt Condensation Approach
Published on: June 10, 2021
A Safe Approach to meta-Fluorinated Pyridines
Oleksandra Rushchak1, Vadym Sham1,2, Bohdan Dansberg3
1Enamine Ltd, Kyiv, Ukraine.
None:
Since 1947, the Balz-Schiemann reaction has remained the most popular method for the synthesis of meta-fluoropyridines. The method involves dangerous pyridyl diazonium salts and has led to numerous documented explosions. A safe alternative to meta-fluoropyridines has now been developed on the basis of a 1,3-disconnection strategy.
More Related Videos
09:04Identifying Per- and Polyfluorinated Chemical Species with a Combined Targeted and Non-Targeted-Screening High-Resolution Mass Spectrometry Workflow
Published on: April 18, 2019
11:03Automated Radiochemical Synthesis of [18F]3F4AP: A Novel PET Tracer for Imaging Demyelinating Diseases
Published on: May 29, 2017