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A Safe Approach to meta-Fluorinated Pyridines.

Oleksandra Rushchak¹, Vadym Sham^1,2, Bohdan Dansberg³

¹Enamine Ltd, Kyiv, Ukraine.

Angewandte Chemie (International Ed. in English)

|June 16, 2026

Summary

This summary is machine-generated.

A new, safer method for synthesizing meta-fluoropyridines has been developed, replacing the hazardous Balz-Schiemann reaction. This approach utilizes a 1,3-disconnection strategy, avoiding dangerous intermediates and explosions.

Keywords:

fluorine heterocycles medicinal chemistry practical synthesis pyridine

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Area of Science:

Organic Chemistry
Synthetic Chemistry

Background:

The Balz-Schiemann reaction, established in 1947, is the primary method for synthesizing meta-fluoropyridines.
This reaction involves hazardous pyridyl diazonium salts, posing significant safety risks and documented explosion incidents.

Purpose of the Study:

To develop a novel and safe alternative for the synthesis of meta-fluoropyridines.
To circumvent the dangers associated with the traditional Balz-Schiemann reaction.

Main Methods:

Implementation of a 1,3-disconnection strategy for retrosynthetic analysis.
Development of new synthetic routes based on the 1,3-disconnection approach.

Main Results:

A safe and viable alternative synthetic route to meta-fluoropyridines has been successfully developed.
The new method avoids the use of dangerous pyridyl diazonium salts.

Conclusions:

The developed 1,3-disconnection strategy offers a significantly safer alternative to the Balz-Schiemann reaction for meta-fluoropyridine synthesis.
This breakthrough enhances safety in synthetic organic chemistry, particularly for fluorinated heterocycles.