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Published on: December 3, 2011
Tracking the Trail of Monkeypox: From Origins to Outbreak Control.
Asha Jangir1, Abhishek Swami1, Neha Kumari1
1Department of Biotechnology, School of Life Sciences, Central University of Rajasthan, Bandarsindri, Kishangarh, Ajmer, Rajasthan, India.
Monkeypox virus (MPXV) re-emerged as a global health concern, causing over 100,000 cases worldwide by 2024. This review covers MPXV epidemiology, clinical aspects, diagnostics, vaccines, and therapeutics for public health preparedness.
Area of Science:
- Virology
- Epidemiology
- Public Health
Background:
- Monkeypox virus (MPXV), a zoonotic disease, re-emerged globally in 2022.
- MPXV transmission occurs via animal-to-human and human-to-human contact, resembling smallpox.
- Over 100,000 cases were documented worldwide between 2022-2024, prompting a PHEIC declaration.
Purpose of the Study:
- Provide a comprehensive overview of MPXV.
- Detail viral structure, life cycle, clinical features, diagnostics, vaccines, and therapeutics.
- Identify challenges and opportunities for MPXV surveillance, prevention, and treatment.
Main Methods:
- Literature review of MPXV epidemiology, clinical manifestations, and control strategies.
- Synthesis of current data on MPXV diagnostics, vaccines, and therapeutics.
- Analysis of global public health preparedness for MPXV.
Main Results:
- MPXV outbreaks have significantly increased globally since 2022.
- A wide range of clinical presentations and diagnostic approaches exist for MPXV.
- Vaccines and therapeutics show promise but challenges in detection and control persist.
Conclusions:
- MPXV poses a significant ongoing global public health threat.
- Integrated strategies are needed to enhance MPXV surveillance, prevention, and treatment.
- This review serves as a vital resource for understanding and combating MPXV.
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