Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Disorders of the Male Reproductive System01:20

Disorders of the Male Reproductive System

Men's health issues are increasingly recognized as significant, with several conditions posing common threats. Among these, testicular cancer is especially prevalent in younger men, particularly those aged 20 to 35 years. The disease often manifests as a painless mass in the testicles, sometimes accompanied by a sensation of heaviness or a dull ache.
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra. Symptoms...
Nondisjunction01:29

Nondisjunction

During meiosis, chromosomes occasionally separate improperly. This occurs due to failure of homologous chromosome separation during meiosis I or failed sister chromatid separation during meiosis II. In some species, notably plants, nondisjunction can result in an organism with an entire additional set of chromosomes, which is called polyploidy. In humans, nondisjunction can occur during male or female gametogenesis and the resulting gametes possess one too many or one too few chromosomes.
Nondisjunction01:29

Nondisjunction

During meiosis, chromosomes occasionally separate improperly. This occurs due to failure of homologous chromosome separation during meiosis I or failed sister chromatid separation during meiosis II. In some species, notably plants, nondisjunction can result in an organism with an entire additional set of chromosomes, which is called polyploidy. In humans, nondisjunction can occur during male or female gametogenesis and the resulting gametes possess one too many or one too few chromosomes.
Sex-linked Disorders01:43

Sex-linked Disorders

Like autosomes, sex chromosomes contain a variety of genes necessary for normal body function. When a mutation in one of these genes results in biological deficits, the disorder is considered sex-linked.
X and Y Chromosomes02:32

X and Y Chromosomes

Among mammals, the gender of an organism is determined by the sex chromosomes. Humans have two sex chromosomes, X and Y. Every human diploid cell has 22 pairs of autosomes and one pair of sex chromosomes. A human female has two X chromosomes, while a male has one X chromosome and one Y chromosome.
The germline cells such as egg and sperm cells carry only half the number of chromosomes, i.e., 22 autosomes and one sex chromosome. All eggs have an X chromosome, while sperm cells can carry an X or...
Karyotyping01:17

Karyotyping

Describing the number and physical features of chromosomes can reveal abnormalities that underlie genetic diseases. This description is facilitated by special staining techniques that produce a particular banding pattern on each chromosome. State-of-the-art techniques make this approach even more powerful, enabling the detection of individual genes that cause disease.A Simple Chromosome Staining Technique Provides Valuable Scientific InsightSome genetic diseases can be detected by looking at...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Beyond semen analysis: in men with normal semen parameters telomere attrition and oxidative imbalance distinguish those fertile from those with infertility.

Journal of translational medicine·2026
Same author

Pathophysiology-Based Classification of Male Infertility: Evidence from an 800-patient Prospective Cohort.

The Journal of clinical endocrinology and metabolism·2026
Same author

Semen Quality in Transgender Individuals Seeking Fertility Preservation.

Andrology·2026
Same author

Differential effects of legacy and new-generation perfluoro-alkyl substances on in vitro differentiation and immunoglobulins production by B cells.

Environment international·2026
Same author

Metformin Redirects Autophagy from Bulk Turnover to Mitochondrial Clearance.

bioRxiv : the preprint server for biology·2026
Same author

Re: World Health Organization Guideline for the Prevention, Diagnosis, and Treatment of Infertility (2025)-Concern about the diagnosis and treatment of male factor infertility: the position of the Italian Society of Andrology and Sexual Medicine, the Italian Society of Endocrinology, and the Italian Society of Fertility and Sterility and Reproductive Medicine.

Fertility and sterility·2026
Same journal

Reinke Crystals are Immunoreactive for Purine-Synthesising Metabolic Enzymes.

Andrology·2026
Same journal

The Case for Limiting the Number of Offspring per Gamete Donor: A Response to Pennings.

Andrology·2026
Same journal

Feminizing Therapy in People With Klinefelter Syndrome and Gender Incongruence: Considerations for Treatment Without Testosterone Blockers.

Andrology·2026
Same journal

Author Reply: Erectile Dysfunction, Anxiety, Perceived Stress, and Insomnia Are More Common Among Acquired Premature Ejaculation Patients in Contrast to Other Premature Ejaculation Syndromes.

Andrology·2026
Same journal

Clomiphene Citrate in off-Label Post-Cycle Therapy: Mechanisms, Efficacy and Diagnostic Challenges in Endocrine Recovery Following Anabolic Steroid Use.

Andrology·2026
Same journal

Machine Learning-Based Prediction of Sperm Retrieval Outcomes in Patients With Klinefelter Syndrome: A Multicenter Study With External Validation.

Andrology·2026
See all related articles

Related Experiment Video

Updated: Jun 17, 2026

Exploring X Chromosomal Aberrations in Ovarian Cells by Using Fluorescence In Situ Hybridization
11:08

Exploring X Chromosomal Aberrations in Ovarian Cells by Using Fluorescence In Situ Hybridization

Published on: April 7, 2023

Neoplastic Risk in Patients With Klinefelter Syndrome.

Andrea Graziani1,2, Giuseppe Grande2, Riccardo Selice2

  • 1Department of Medicine, University of Padova, Padova, Italy.

Andrology
|June 16, 2026
PubMed
Summary
This summary is machine-generated.

Klinefelter syndrome (KS) increases cancer risk, particularly breast cancer and mediastinal germ cell tumors. Patients with KS require regular clinical follow-up for early diagnosis and management of associated neoplastic risks.

Keywords:
Klinefelter syndromehypogonadismmale breast cancerneoplasmoncologytestosterone replacement therapy

More Related Videos

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer
07:25

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer

Published on: March 6, 2018

Related Experiment Videos

Last Updated: Jun 17, 2026

Exploring X Chromosomal Aberrations in Ovarian Cells by Using Fluorescence In Situ Hybridization
11:08

Exploring X Chromosomal Aberrations in Ovarian Cells by Using Fluorescence In Situ Hybridization

Published on: April 7, 2023

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer
07:25

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer

Published on: March 6, 2018

Area of Science:

  • Endocrinology
  • Oncology
  • Genetics

Background:

  • Klinefelter syndrome (KS) is a genetic condition associated with gonadal dysfunction.
  • Beyond gonadal issues, KS patients face risks of extragonadal complications, including neoplastic diseases.

Purpose of the Study:

  • To review the clinical evidence linking Klinefelter syndrome (KS) with various neoplastic diseases.
  • To offer management recommendations for KS patients concerning their cancer risk.

Main Methods:

  • A comprehensive literature search was performed using PubMed.
  • Keywords included "Klinefelter syndrome," "cancer," "neoplasm," "breast cancer," "germ cell tumor," "lymphoma," and "testosterone replacement therapy."

Main Results:

  • KS is linked to increased risks of breast cancer and mediastinal germ cell tumors.
  • An elevated risk of hematological malignancies, specifically non-Hodgkin lymphoma and leukemia, is observed in KS patients.
  • Evidence regarding testicular cancer risk in KS is inconclusive, while prostate cancer risk appears lower.

Conclusions:

  • The complex nature of KS necessitates regular clinical monitoring.
  • Targeted investigations can aid in the early detection and management of comorbidities, including cancers, in KS patients.