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Updated: Jun 17, 2026

A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia
06:01

A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia

Published on: August 18, 2015

A bibliometric analysis of cardioembolic stroke utilizing HistCite Pro, CiteSpace, and VOSviewer

Dandan Liu1,2, Changyong Fu3, Shiyao Zhang2

  • 1Department of Neurology, The People's Hospital of Danyang, Affiliated Danyang Hospital of Nantong University, Zhenjiang, Jiangsu, China.

Medicine
|June 16, 2026
PubMed

Insights

Cardioembolic stroke research is rapidly advancing, with a surge in publications and international collaboration. Key areas include biomarkers, direct oral anticoagulants for embolic stroke of undetermined source (ESUS), and atrial cardiopathy.

Area of Science:

  • Neurology
  • Bibliometrics
  • Public Health

Background:

  • Cardioembolic stroke (CES) leads to poorer outcomes compared to other ischemic stroke types.
  • A significant increase in research output necessitates a bibliometric analysis to understand trends and contributors.
  • This study aims to analyze the developmental trajectory and key research areas in CES.

Purpose of the Study:

  • To conduct a comprehensive bibliometric analysis of cardioembolic stroke (CES) research.
  • To identify developmental trends, key research hotspots, and major contributors in the CES field.
  • To analyze publication characteristics, keyword networks, and collaborative patterns in CES research.

Main Methods:

  • Bibliometric analysis of 5498 publications from Web of Science Core Collection (2011-2024).
  • Utilized HistCite Pro, CiteSpace, and VOSviewer for data analysis, keyword, and network mapping.
  • Examined publication characteristics, institutional contributions, and country/region participation.

Main Results:

  • The US and Journal of Stroke & Cerebrovascular Diseases were leading contributors.
  • Keyword analysis revealed 6 clusters focusing on biomarkers, CES causes, and direct oral anticoagulant trials for embolic stroke of undetermined source (ESUS).
  • Recent research hotspots include direct oral anticoagulants, ESUS, Mendelian randomization, and atrial cardiopathy.

Conclusions:

  • CES research shows rapid progress with extensive international collaboration.
  • Strengthening global research partnerships can further advance the field.
  • Future research should focus on refined etiological phenotyping and personalized secondary prevention for ESUS and related conditions.
Abstract

Keywords:
CiteSpaceHistCite ProVOSviewerbibliometric analysiscardioembolic strokecryptogenic strokeembolic stroke of undetermined sourcestroke

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