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Related Experiment Video

Updated: Jun 17, 2026

Establishment and Evaluation of a Sheep Model of Full-thickness Osteochondral Defect
05:23

Establishment and Evaluation of a Sheep Model of Full-thickness Osteochondral Defect

Published on: April 14, 2026

Natural Biomaterials for Osteochondral Repair: From Source to Strategy.

Hengyu Liu1, Hanyang Zhang1, Wenbo Yang1,2

  • 1Department of Orthopedic Surgery, The Second Hospital of Jilin University, Changchun, P. R. China.

Advanced Healthcare Materials
|June 16, 2026
PubMed
Summary

Natural biomaterials are crucial for osteochondral tissue repair, offering advantages over synthetics. Standardization is needed for wider clinical use of these effective regenerative medicine scaffolds.

Keywords:
biological origindecellularized extracellular matrixnatural biomaterialsosteochondral repair

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Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Tissue Engineering

Background:

  • Osteochondral tissue repair is challenging due to complex structure and poor healing.
  • Natural biomaterials offer superior biocompatibility and bioactivity compared to synthetics.
  • Natural materials are well-suited for mimicking native tissue microenvironments.

Purpose of the Study:

  • To systematically review natural biomaterials for osteochondral repair.
  • To categorize materials by biological origin (human, animal, plant, microbial).
  • To discuss source-specific properties, repair mechanisms, and applications.

Main Methods:

  • Systematic review of natural biomaterials in osteochondral repair.
  • Categorization based on biological origin.
  • Analysis of decellularization strategies for animal-derived materials.

Main Results:

  • Natural biomaterials are extensively used, with 91.5% of approved products since 2000 incorporating them.
  • Different biological origins (human, animal, plant, microbial) offer unique properties.
  • Decellularization methods significantly impact scaffold bioactivity and immunogenicity.

Conclusions:

  • Natural biomaterials are clinically relevant and effective for osteochondral repair.
  • Standardization of preparation, quality control, and evaluation is critical for clinical translation.
  • Addressing standardization challenges will accelerate the adoption of novel biomaterials.