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Amine Transaminase-Catalyzed Enantioselective Synthesis of Cyclohexylidene-Based Axially Chiral Amines

Haiyan Xu1,2,3, Lin Yang3,4, Li Zhang1,2

  • 1School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, Henan 450001, P. R. China.

Organic Letters
|June 16, 2026
PubMed

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Direct alkylation of ammonia produces polyalkylated amines, along with a quaternary ammonium salt. To exclusively prepare primary amines, the azide synthesis method can be used.
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