In situ Grown Curcumin-Loaded MOFs on SrCO₃ Functionalized Scaffold for Enhanced Osteogenic Differentiation via...

To address the challenges posed by excessive inflammatory responses and reactive oxygen species (ROS) in the complex microenvironment during pathological bone defect repair, this study developed a composite scaffold. First, zeolitic imidazolate framework-8 (ZIF-8) loaded with curcumin (CCM) was grown in situ on the surface of strontium carbonate (SrCO₃) to form SrCO₃@CZIF-8 composite particles with a core-shell structure. Subsequently, these particles were integrated into a poly-l-lactic acid (PLLA) matrix using selective laser sintering technology. Experimental results indicate that the CCM and Zn²⁺ ions released during scaffold degradation effectively scavenge hydroxyl radicals (with a scavenging efficiency of 61.98% after 24 h) and significantly alleviate inflammatory responses. Furthermore, the released Sr²⁺ ions enhance osteogenic activity and promote osteogenic differentiation, suggesting that this scaffold holds potential for bone defect repair in complex pathological environments.