Related Experiment Video
Updated: Jun 17, 2026

Association Between Sleep Quality and Cognitive Symptoms in Patients with Major Depressive Disorder
Published on: April 26, 2024
Resilience and Quality of Life in Mild Traumatic Brain Injury: Serial Mediating Role of Sleep Quality and Depression
Ya-Wen Hsiao1, Hsiang-Yun Lan, Ching-Yuan Ma
1Author Affiliations: School of Nursing, College of Nursing, National Defense Medical University, Taipei, Taiwan (Lan and Chiang); Department of Nursing, Tri-Service General Hospital, Taipei, Taiwan (Hsiao and Ma); Department of Neurological Surgery, Tri-Service General Hospital, National Defense Medical University, Taipei, Taiwan (Hueng); and School of Mathematics, Tamkang University, New Taipei City, Taiwan (Chang).
Objective:
To investigate the influence of resilience on quality of life (QoL) in patients with mild traumatic brain injury (mTBI), and to evaluate the mediating roles of sleep quality and depression in the relationship. Setting: Emergency and neurosurgical outpatient departments in regional medical center in northern Taiwan.
Participants:
A total of 310 adults patients diagnosed with mTBI were recruited between 3 and 12 months postinjury.
Design:
A cross-sectional observational study using self-report measures and serial-mediation analysis.
Main Measures:
Participants completed the Resilience Scale for Adults, Pittsburgh Sleep Quality Index, Beck Depression Inventory-II, and the WHO Quality of Life-BREF. Data were analyzed using PROCESS Model 6 with 5000 bootstrap resamples.
Results:
Resilience was associated with improved QoL, both directly and indirectly through sleep quality and depression. In particular, resilience predicted higher sleep quality and fewer depressive symptoms. Poor sleep quality was associated with greater depressive symptoms, which in turn predicted lower QoL. All direct and indirect pathways in the serial mediation model were significant (P < 0.001), and the model explained 54% of the variance in QoL.
Conclusion:
Our findings suggest that resilience influences QoL through sleep quality and depression. Enhancing resilience and sleep quality may reduce depressive symptoms and improve overall well-being in patients recovering from mTBI.
More Related Videos
05:01Murine Model of Controlled Cortical Impact for the Induction of Traumatic Brain Injury
Published on: August 16, 2019
06:23A Chronic Sleep Fragmentation Model using Vibrating Orbital Rotor to Induce Cognitive Deficit and Anxiety-Like Behavior in Young Wild-Type Mice
Published on: September 22, 2020
Related Concept Videos
Insufficient Sleep and Sleep Deprivation
Sleep deprivation is a more severe form of sleep loss...
Substance Use Disorders Affecting Sleep
Understanding the concepts of physical dependence,...
Understanding Sleep
The circadian rhythm, a nearly 24-hour cycle, is deeply influenced by environmental light cues. Light exposure directly affects the hypothalamus, which in turn regulates...
Traumatic Brain Injury l: Introduction
Sleepwalking and Sleep Talking
Factors that increase the likelihood of sleepwalking include sleep deprivation and alcohol consumption. Contrary to common beliefs, it is safe...
Depression: Overview