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Updated: Jun 17, 2026

Synthesis of Hypervalent Iodonium Alkynyl Triflates for the Application of Generating Cyanocarbenes
Published on: September 8, 2013
Hypervalent iodine-mediated cyclization of N-vinyl amides for the synthesis of 4-functionalized dihydrooxazolines
Jiwoo Lee1, Suhui Kim1, Chang Sung Hong2
1New Drug Development Center, Daegu-Gyeongbuk Medical Innovation Foundation, Daegu 41061, Korea. kbhong@kmedihub.re.kr.
Abstract:
A hypervalent iodine-mediated heterofunctionalization of N-vinyl amides has been developed using PhI(OAc)2/KI under mild conditions. This method provides efficient access to 4-aminated and 4-acetoxylated dihydrooxazolines with broad functional-group tolerance, accommodating electron-rich, electron-deficient, sterically hindered, and heteroaromatic substrates. The operational simplicity, broad substrate generality, and selective product formation underscore the synthetic utility of this approach for the difunctionalization of unactivated alkenes.
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