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Updated: Jun 17, 2026
Facile Preparation of 4-Substituted Quinazoline Derivatives
Published on: February 15, 2016
Stereochemical control and its consequences in VO(acac)2 complexes: an integrated study of trans/cis isomerism with
Barbara Matusiewicz1, Aleksandra Tesmar1, Jakub Brzeski1
1Faculty of Chemistry, University of Gdańsk, Wita Stwosza 63, 80-308 Gdańsk, Poland. dariusz.wyrzykowski@ug.edu.pl.
Abstract:
In this study, a combination of experimental and theoretical methods was applied to rigorously characterize the factors controlling the stereochemistry of three novel adducts: VO(acac)2(trans-quinoline) (1), VO(acac)2(trans-isoquinoline) (2), and VO(acac)2(cis-isoquinoline) (3). Based on X-ray measurements, spectroscopic analysis (IR and UV-Vis) and density functional theory (DFT) calculations, it was demonstrated that the coordination mode is predominantly governed by steric factors. While the trans isomer is favoured both kinetically and thermodynamically in most cases, the cis isomer becomes viable when the favourable geometry of the ligand offsets the inherent steric and entropic penalties, as shown for isoquinoline. Electronic structure analysis revealed that cis coordination enhances σ-donation to the vanadium center, resulting in a stronger, more polarized V-N bond, a red-shifted VO stretching frequency, and a blue-shifted d-d transition. These findings establish clear structure-property relationships linking ligand architecture to coordination geometry, electronic structure, and thermal stability. The insights gained provide a predictive framework for the rational design of VO(acac)2-based complexes with tailored stereochemistry and optimized properties for applications in catalysis, materials science, and bioinorganic chemistry.
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