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1Department of Organ Anatomy & Nanomedicine, Yamaguchi University Graduate School of Medicine, 1-1-1 Minami-Kogushi, Ube, Yamaguchi 755-8505, Japan. nakam@yamaguchi-u.ac.jp.
Chemical Communications (Cambridge, England)
|June 16, 2026
Summary
Functional silica materials are advancing theranostics, integrating diagnosis and therapy. This review highlights progress in silica-based platforms for cancer treatment, focusing on imaging-guided radiotherapy and organosilica nanoparticles.
Area of Science:
- Materials Science
- Nanotechnology
- Oncology
Background:
- Theranostics combine diagnosis and therapy using functional materials.
- Silica-based platforms are progressing towards clinical applications.
- Organosilica nanoparticles represent a key class of silica-based materials.
Purpose of the Study:
- To review recent advancements in non-porous silica-based theranostic platforms.
- To focus on organosilica nanoparticles for cancer theranostics.
- To discuss challenges and opportunities in translating silica nanomedicine for global health.
Main Methods:
- Literature review of functional materials for theranostics.
- Emphasis on imaging-guided radiotherapy and radiosensitization.
- Summary of organosilica nanoparticle development for cancer theranostics.
Main Results:
- Non-porous silica platforms show promise for clinical theranostic applications.
- Organosilica nanoparticles are effective cancer theranostic agents.
- Significant progress has been made in developing silica-based nanomedicine.
Conclusions:
- Silica-based theranostics are advancing rapidly, particularly in oncology.
- Organosilica nanoparticles offer unique advantages for cancer diagnosis and therapy.
- Further research is needed to overcome challenges in clinical translation and achieve global health impact.
