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Updated: Jun 17, 2026

Synthesis of pH Dependent Pyrazole, Imidazole, and Isoindolone Dipyrrinone Fluorophores using a Claisen-Schmidt Condensation Approach
Published on: June 10, 2021
One-pot multicomponent synthesis of indole-linked fully substituted fused pyrroles
Swadhin Swaraj Acharya1, Rudranarayan Sutar1, Girija Prasad Mishra2
1Organic Synthesis Laboratory, P. G. Department of Chemistry, Berhampur University, Bhanja Bihar, Berhampur, 760007, Odisha, India. bbp.chem@buodisha.edu.in.
Abstract:
Indoles and pyrroles are valued owing to their natural and pharmaceutical abundance and impressive biological profile. Herein, we report the green and sustainable non-templated synthesis of indole-linked fully substituted fused pyrroles by the multicomponent reactions of arylglyoxals, dimedone, indoles, and anilines. The notable features of the present method include the formation of four new bonds (2 C-C, 2 C-N) under one-pot, catalyst-, and metal-free reaction conditions, and easy isolation of the products by filtration, gram-scale synthesis, and synthesis of pharmaceutically relevant scaffolds.
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