Related Experiment Video
Updated: Jun 17, 2026

Generation of Monoclonal Antibodies Against Natural Products
Published on: April 6, 2019
Advances in the discovery and functional analysis of Anti-infective and immunomodulatory natural products from
Sebastian Götze1, Christine Beemelmanns1,2
1Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), 66123 Saarbrücken, Germany. christine.beemelmanns@helmholtz-hips.de.
Abstract:
Covering: 2018 to 2025Over recent years, metagenomic-driven studies have revealed an enormous encoded repertoire for the biosynthesis of secondary metabolite scaffolds within host-associated microbiota, yet only a small fraction of these chemical scaffolds has been characterized. This review focuses on recent discoveries of natural products with anti-infective and immunomodulatory properties derived from diverse host-associated microbiomes, covering the period from 2018 to 2025. The selected examples span a wide range of anti-infective and immunomodulatory activities, underscoring the deep integration of microbial secondary metabolism with host physiology, while also highlighting the need for more targeted and efficient combined approaches to fully exploit the predicted biosynthetic capacity of microbiomes for anti-infective research and beyond.
More Related Videos
07:28Metabolic Profiling to Determine Bactericidal or Bacteriostatic Effects of New Natural Products using Isothermal Microcalorimetry
Published on: October 29, 2020
09:45Production of Monoclonal Antibodies Targeting Aminopeptidase N in the Porcine Intestinal Mucosal Epithelium
Published on: May 18, 2021
Related Concept Videos
Microorganisms in Medicine and Therapeutics
Human Virome
Humoral Immune Responses
Microbiota Modulation by Antibiotics
Introduction to the Human Microbiota
Defense Mechanism Against Infection
In addition, many body organ systems have unique defenses against infection. The skin is an intact, multilayered surface preventing invasion by microorganisms unless impaired. Mucous membranes lining the mouth, nose, and eyelids are barriers...