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Related Concept Videos

Tumor Immunotherapy01:27

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
Cancer Vaccines01:30

Cancer Vaccines

Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Psychoneuroimmunology: Diabetes and Cancer01:19

Psychoneuroimmunology: Diabetes and Cancer

Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...

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Related Experiment Video

Updated: Jun 17, 2026

Tractable In Vivo Reprogramming of Tumor Cells to Type 1 Conventional Dendritic Cell-like Cells
10:04

Tractable In Vivo Reprogramming of Tumor Cells to Type 1 Conventional Dendritic Cell-like Cells

Published on: August 1, 2025

Immunometabolic Reprogramming: A New Frontier in Cancer Immunotherapy.

Saeed Mohammadi1, Mahmoud Darweesh1, Mina Rahmati1,2

  • 1Immunology Laboratory, Natural and Medical Sciences Research Center, University of Nizwa, Nizwa, Oman.

Current Molecular Medicine
|June 16, 2026
PubMed
Summary
This summary is machine-generated.

Immunometabolism, the link between cell metabolism and immunity, is key for cancer immunotherapy effectiveness. Reprogramming tumor metabolism offers new strategies to boost anti-cancer immunity and overcome treatment resistance.

Keywords:
CAR-T engineeringImmunometabolismcancer heterogeneitycheckpoint blockademetabolic reprogrammingprecision oncology.tumor microenvironment

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Flow Cytometry-Based Isolation and Therapeutic Evaluation of Tumor-Infiltrating Lymphocytes in a Mouse Model of Pancreatic Cancer

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Last Updated: Jun 17, 2026

Tractable In Vivo Reprogramming of Tumor Cells to Type 1 Conventional Dendritic Cell-like Cells
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Published on: August 1, 2025

Flow Cytometry-Based Isolation and Therapeutic Evaluation of Tumor-Infiltrating Lymphocytes in a Mouse Model of Pancreatic Cancer
07:55

Flow Cytometry-Based Isolation and Therapeutic Evaluation of Tumor-Infiltrating Lymphocytes in a Mouse Model of Pancreatic Cancer

Published on: January 17, 2025

Area of Science:

  • Immunology
  • Metabolic pathways
  • Cancer research

Background:

  • Immunometabolism is critical for anti-tumor immunity and cancer immunotherapy efficacy.
  • Understanding metabolic dependencies in immune and cancer cells informs novel therapeutic strategies.
  • Reprogramming the tumor microenvironment's metabolism can enhance anti-cancer responses and overcome immunotherapy resistance.

Purpose of the Study:

  • To provide a comprehensive overview of immunometabolism.
  • To detail key metabolic pathways and regulators in immune and cancer cells.
  • To explore therapeutic opportunities targeting immunometabolism for improved cancer immunotherapy.

Main Methods:

  • Review of fundamental principles of immunometabolism.
  • Analysis of metabolic profiles of immune cell subsets and cancer cells.
  • Discussion of the impact of current immunotherapies on cellular metabolism.

Main Results:

  • Distinct metabolic profiles exist for various immune cell subsets and cancer types.
  • Cellular metabolism significantly influences anti-tumor immune responses and immunotherapy outcomes.
  • Targeting immunometabolism presents promising therapeutic avenues.

Conclusions:

  • Immunometabolic reprogramming is a crucial frontier for enhancing cancer immunotherapy.
  • Targeting metabolic pathways can improve anti-cancer immunity and patient outcomes.
  • Combination strategies involving metabolic modulators show potential for overcoming treatment resistance.