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Tractable In Vivo Reprogramming of Tumor Cells to Type 1 Conventional Dendritic Cell-like Cells
Published on: August 1, 2025
Immunometabolic Reprogramming: A New Frontier in Cancer Immunotherapy
Saeed Mohammadi1, Mahmoud Darweesh1, Mina Rahmati1,2
1Immunology Laboratory, Natural and Medical Sciences Research Center, University of Nizwa, Nizwa, Oman.
Current Molecular Medicine
|June 16, 2026
Summary
Immunometabolism, the link between cell metabolism and immunity, is key for cancer immunotherapy effectiveness. Reprogramming tumor metabolism offers new strategies to boost anti-cancer immunity and overcome treatment resistance.
Area of Science:
- Immunology
- Metabolic pathways
- Cancer research
Background:
- Immunometabolism is critical for anti-tumor immunity and cancer immunotherapy efficacy.
- Understanding metabolic dependencies in immune and cancer cells informs novel therapeutic strategies.
- Reprogramming the tumor microenvironment's metabolism can enhance anti-cancer responses and overcome immunotherapy resistance.
Purpose of the Study:
- To provide a comprehensive overview of immunometabolism.
- To detail key metabolic pathways and regulators in immune and cancer cells.
- To explore therapeutic opportunities targeting immunometabolism for improved cancer immunotherapy.
Main Methods:
- Review of fundamental principles of immunometabolism.
- Analysis of metabolic profiles of immune cell subsets and cancer cells.
- Discussion of the impact of current immunotherapies on cellular metabolism.
Main Results:
- Distinct metabolic profiles exist for various immune cell subsets and cancer types.
- Cellular metabolism significantly influences anti-tumor immune responses and immunotherapy outcomes.
- Targeting immunometabolism presents promising therapeutic avenues.
Conclusions:
- Immunometabolic reprogramming is a crucial frontier for enhancing cancer immunotherapy.
- Targeting metabolic pathways can improve anti-cancer immunity and patient outcomes.
- Combination strategies involving metabolic modulators show potential for overcoming treatment resistance.
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