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Self-assembly for cuproptosis-based cancer therapy and imaging
Qiyue Wang1, Hui Du2, Xinting Li1
1Department of Emergency and Critical Disease, Songjiang Research Institute, Shanghai Key Laboratory of Emotions and Affective Disorders (LEAD), Songjiang Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 201600, China. lfy@shsmu.edu.cn.
Stimuli-responsive nanoplatforms that self-assemble are advancing cancer therapy by inducing cuproptosis (copper-dependent cell death). These dynamic systems offer precise control for enhanced cancer treatment and imaging.
Area of Science:
- Biomedical Engineering
- Nanotechnology
- Cancer Therapy
Background:
- Cuproptosis, a copper-dependent programmed cell death, shows promise for cancer treatment.
- Existing research focuses on cuproptosis mechanisms and inducers, overlooking self-assembly nanoplatforms.
- Stimuli-responsive, self-assembly nanoplatforms for cuproptosis remain underexplored.
Purpose of the Study:
- To comprehensively review advancements in stimuli-responsive, self-assembly nanosystems for cuproptosis-based cancer therapy and imaging.
- To elucidate cuproptosis mechanisms and the design principles of self-assembly inducers.
- To highlight integrated applications and future challenges in clinical translation.
Main Methods:
- Review of recent literature on self-assembly nanoplatforms for cuproptosis.
- Analysis of copper-ion coordination chemistry and intermolecular forces in inducer design.
- Exploration of stimuli-responsive transformations and synergistic therapeutic strategies.
Main Results:
- Self-assembly inducers leverage copper-ion coordination for spatiotemporal regulation.
- Nanoassemblies exhibit intelligent transformations in response to endogenous/exogenous stimuli.
- Integration with synergistic therapies and imaging guidance enhances cancer treatment potential.
Conclusions:
- Stimuli-responsive self-assembly nanoplatforms offer precise control over cuproptosis activation.
- These systems hold significant promise for advanced cancer therapy and diagnostics.
- Addressing challenges is crucial for the clinical translation of cuproptosis nanoplatforms.
