Related Experiment Video
Updated: Jun 17, 2026

Translating Extracellular Electron Transfer Activities with Organic Electrochemical Transistors
Published on: January 31, 2025
Interface engineering in organic electrochemical transistors toward multifunctional bioelectronics
Guo Liu1, Siyu Di1, Lianrui Cheng1
1School of Chemical Sciences, University of Chinese Academy of Sciences, Beijing 101408, China. fjiaozhang@ucas.ac.cn.
None:
Bioelectronics enables bidirectional transduction between biological and electronic signals, with organic electrochemical transistors (OECTs) emerging as a leading platform due to their volumetric doping, high transconductance, low-voltage operation, and compatibility with soft, aqueous environments. While conjugated polymers provide versatile and scalable device architectures, the performance and functionality of OECTs are fundamentally governed by interfacial processes. This review focuses on how the interface engineering-across electrolyte/channel, channel/electrode, and device/tissue interfaces-directly controls ion transport, charge injection, capacitance, and biocompatibility. We summarize recent advances showing that tailored interfacial design enables multifunctional applications, including high-accuracy biosensing, bio-synaptic emulation, and integrated neuromorphic computing. We further outline key strategies for engineering these interfaces to advance next-generation OECT-based bioelectronics, and conclude by discussing remaining challenges and future directions.
Related Concept Videos
Interfacial Electrochemical Methods: Overview
Field Effect Transistor
Electrochemical Systems

