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Updated: Jun 17, 2026

Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents
Published on: May 28, 2014
Development and comparative study of a hydrophilic bis-triazolyl-phenanthroline ligand and two bis-triazolyl-pyridine
Yong Qiang Wan1, Yang-Yang Zhang2, Shi Lin Zhang1
1School of Nuclear Science and Technology, Lanzhou University, Lanzhou, China. pavlem@lzu.edu.cn.
Abstract:
A comprehensive study of three novel hydrophilic CHON-compliant ligands, two hydrophilized with longer diethylene glycol chains (DEG-BTrzPhen and DEG-PTD) and one with shorter hydroxyethyl chains (HE-PTD), encompassing synthesis, solubility, solvent extraction, coordination, spectral, crystallographic and computational studies is presented herein. Experimental results demonstrated that under weakly acidic conditions, these ligands exhibited selectivity for Am(III) vs. Eu(III), with maximum separation factors (SFEu/Am) reaching 74, 240, and 127 for DEG-BTrzPhen, DEG-PTD, and HE-PTD, respectively. Among these ligands, DEG-PTD, a derivative of the well-known PTD, exhibits exceptionally high aqueous solubility, offering a significant technological advantage. With its overall characteristics, being CHON-compliant, selective, cheap, and with high aqueous solubility even at very high concentrations, the DEG-PTD ligand is a viable option for actual industrial applications.
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