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Updated: Jun 17, 2026
Manufacture and Drug Delivery Applications of Silk Nanoparticles
Published on: October 8, 2016
Ensemble and single particle analysis of doxorubicin silk nanoparticles
Napaporn Roamcharern1,2, Panida Punnabhum1, Harriet Graham1
1Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, 161 Cathedral St., Glasgow G4 0RE, Scotland, UK. zahra.rattray@strath.ac.uk.
Abstract:
Adsorption-loaded silk nanoparticles exploit protein electrostatics and β-sheet-rich architecture to achieve high doxorubicin loading and pH-responsive release, while preserving silk structure. Ensemble and single-particle analyses reveal exceptional formulation uniformity, while in vitro studies confirm preserved cytotoxicity against MDA-MB-231 human breast cancer cells.
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