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Related Experiment Video

Updated: Jun 17, 2026

Microgel-Extracellular Matrix Composite Support for the Embedded 3D Printing of Human Neural Constructs
07:48

Microgel-Extracellular Matrix Composite Support for the Embedded 3D Printing of Human Neural Constructs

Published on: May 5, 2023

A guest-host hydrogel for neural tissue engineering applications.

Gregory Jensen1, Alexis Williams2, Juhi Khandelwal1

  • 1Chemical Engineering, School of Engineering of Matter, Transport, and Energy, Arizona State University, Tempe, AZ, USA. julianne.holloway@asu.edu.

Journal of Materials Chemistry. B
|June 16, 2026
PubMed
Summary
This summary is machine-generated.

Researchers developed an injectable hyaluronic acid hydrogel for neural tissue engineering. This biocompatible hydrogel shows promise for treating neurological injuries and disorders by supporting tissue healing and regeneration.

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Fabrication of Micropatterned Hydrogels for Neural Culture Systems using Dynamic Mask Projection Photolithography
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Area of Science:

  • Biomaterials Science
  • Neuroscience
  • Tissue Engineering

Background:

  • Neurological injuries and disorders are a major cause of disability worldwide.
  • Current treatments for neurological conditions are limited in addressing underlying disease mechanisms.
  • Injectable hydrogels offer a promising minimally invasive approach for neural tissue engineering.

Purpose of the Study:

  • To develop an injectable hyaluronic acid (HA) hydrogel for neural tissue engineering applications.
  • To characterize the material properties and biocompatibility of the developed HA hydrogel.
  • To assess the potential of the HA hydrogel as a platform for neural regeneration.

Main Methods:

  • Development of an injectable HA hydrogel using guest-host interactions (cyclodextrin and adamantane).
  • Rheological characterization to optimize HA content for brain tissue-like properties.
  • Assessment of shear-thinning, self-healing, and *in vitro* biocompatibility (LDH assay) with primary mouse astrocytes.
  • *In vivo* intracortical injection in mice to evaluate inflammatory response.

Main Results:

  • The HA hydrogel's properties were optimized by adjusting HA content to mimic endogenous brain tissue.
  • The hydrogel demonstrated desirable shear-thinning and self-healing characteristics for injectability.
  • *In vitro* tests confirmed the hydrogel's biocompatibility with astrocytes.
  • *In vivo* injections showed a modest inflammatory response, comparable to a control polymer.

Conclusions:

  • An injectable, biocompatible HA hydrogel was successfully developed.
  • The hydrogel possesses suitable properties for minimally invasive delivery and neural tissue support.
  • This HA hydrogel platform holds potential for future neural tissue engineering and regeneration strategies.