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Updated: Jun 17, 2026

Peptide-based Identification of Functional Motifs and their Binding Partners
Published on: June 30, 2013
Human Tat-derived cyclic peptide destabilizes the MALAT1 ENE triple helix and attenuates expression
Pranotosh Das1,2, Shuvam Mandal1,2, Manish Debnath1,2
1Organic and Medicinal Chemistry Division, CSIR-Indian Institute of Chemical Biology, Kolkata 700032, India. manish.debnath.iicb@csir.res.in.
None:
Herein, we report the development of a cyclic peptide targeting the 3'-end ENE triple helix of the metastatic long non-coding RNA MALAT1. The peptide selectively binds and destabilizes the RNA triple helix, surpasses its linear analog, reduces MALAT1 levels, disrupts spheroid morphogenesis, and induces apoptosis in A549 lung cancer cells.
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