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Loeffler Endocarditis: Multimodality Imaging of a Common Cardiac Phenotype in Distinct Hypereosinophilic Syndromes

Tooba Salar1, Scott Feitell1, Vishal Parikh1

  • 1Rochester General Hospital, Rochester, New York, USA.

JACC. Case Reports
|June 16, 2026
PubMed

Insights

Loeffler endocarditis, a heart condition linked to hypereosinophilic syndromes, presents challenges in early diagnosis. Imaging is key for identifying cardiac damage and guiding targeted therapies for better patient outcomes.

Area of Science:

  • Cardiology
  • Hematology
  • Medical Imaging

Background:

  • Loeffler endocarditis is a severe cardiac manifestation of hypereosinophilic syndromes.
  • It involves endomyocardial fibrosis and intracardiac thrombosis.
  • Nonspecific symptoms often delay diagnosis.
Abstract

Keywords:
FIP1L1-PDGFRALoeffler endocarditisendomyocardial fibrosishypereosinophilic syndromeintracardiac thrombosis

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