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  3. Aprepitant For Oculoplastic Surgeries.
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  3. Aprepitant For Oculoplastic Surgeries.

Related Experiment Video

Surgical Correction for Pediatric Epiblepharon and Trichiasis
03:59

Surgical Correction for Pediatric Epiblepharon and Trichiasis

Published on: July 8, 2025

Aprepitant for Oculoplastic Surgeries.

Kevin Wu1,2,3, Dianne Schlachter4,5,6, Evan Black4,5,6

  • 1Department of Ophthalmology, Icahn School of Medicine at Mount Sinai.

Ophthalmic Plastic and Reconstructive Surgery
|June 16, 2026

View abstract on PubMed

Summary
This summary is machine-generated.

Aprepitant effectively reduced postoperative nausea and vomiting (PONV) in oculoplastic surgery patients. This antiemetic medication decreased symptom severity and the need for rescue antiemetics and opioids.

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Area of Science:

  • Anesthesiology
  • Pharmacology
  • Surgical Care

Background:

  • Postoperative nausea and vomiting (PONV) significantly impacts patient recovery and healthcare costs.
  • Effective PONV prophylaxis is crucial in surgical patient management.

Purpose of the Study:

  • To evaluate the efficacy of 40 mg oral aprepitant in reducing PONV incidence and severity.
  • To compare aprepitant with placebo in patients undergoing oculoplastic procedures.

Main Methods:

  • A randomized, double-blind, placebo-controlled study design.
  • 40 mg oral aprepitant or placebo administered preoperatively.
  • Assessment of PONV severity using the modified Baxter Nausea Scale; data on rescue antiemetic and opioid use collected.

Main Results:

  • Significantly lower nausea severity scores in the aprepitant group.
  • Reduced incidence of vomiting and decreased need for rescue antiemetics (ondansetron) and opioids.
  • Aprepitant exhibited a safety profile consistent with prior research.

Conclusions:

  • Aprepitant is effective in mitigating PONV and reducing rescue medication requirements.
  • Supports the integration of aprepitant into standard PONV prophylaxis protocols for oculoplastic surgery.