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Aprepitant for Oculoplastic Surgeries
Kevin Wu1,2,3, Dianne Schlachter4,5,6, Evan Black4,5,6
1Department of Ophthalmology, Icahn School of Medicine at Mount Sinai.
Ophthalmic Plastic and Reconstructive Surgery
|June 16, 2026
Summary
Aprepitant effectively reduced postoperative nausea and vomiting (PONV) in oculoplastic surgery patients. This antiemetic medication decreased symptom severity and the need for rescue antiemetics and opioids.
Area of Science:
- Anesthesiology
- Pharmacology
- Surgical Care
Background:
- Postoperative nausea and vomiting (PONV) significantly impacts patient recovery and healthcare costs.
- Effective PONV prophylaxis is crucial in surgical patient management.
Purpose of the Study:
- To evaluate the efficacy of 40 mg oral aprepitant in reducing PONV incidence and severity.
- To compare aprepitant with placebo in patients undergoing oculoplastic procedures.
Main Methods:
- A randomized, double-blind, placebo-controlled study design.
- 40 mg oral aprepitant or placebo administered preoperatively.
- Assessment of PONV severity using the modified Baxter Nausea Scale; data on rescue antiemetic and opioid use collected.
Main Results:
- Significantly lower nausea severity scores in the aprepitant group.
- Reduced incidence of vomiting and decreased need for rescue antiemetics (ondansetron) and opioids.
- Aprepitant exhibited a safety profile consistent with prior research.
Conclusions:
- Aprepitant is effective in mitigating PONV and reducing rescue medication requirements.
- Supports the integration of aprepitant into standard PONV prophylaxis protocols for oculoplastic surgery.
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