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Selection Rules: Thermal Activation
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Molecules that possess multiple chiral centers can afford a large number of stereoisomers. For instance, while some molecules like 2-butanol have one chiral center, defined as a tetrahedral carbon atom with four different substituents attached, several molecules like butane-2,3-diol have multiple chiral centers. A simple formula to predict the number of stereoisomers possible for a molecule with n chiral centers is 2n. However, there can be a lower number where some of the stereoisomers are...
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Spin-Selective Oxygen Evolution in Chiral Molecule-Intercalated Layered Double Hydroxides.

Chih-Ying Huang1,2, Cheng-Rong Wu3, Yang-Sheng Lu4

  • 1International Graduate Program of Molecular Science and Technology (NTU-MST), National Taiwan University, Taipei, Taiwan.

Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
|June 16, 2026
PubMed
Summary
This summary is machine-generated.

Chiral-induced spin selectivity (CISS) effect enhances oxygen evolution reaction (OER) catalysts. Intercalating chiral molecules into CoFe-LDH creates a hybrid interface, improving OER performance and kinetics.

Keywords:
chiral‐induced spin selectivityin situ observationlayered double hydroxidesmolecule intercalationoxygen evolution reaction

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Area of Science:

  • Electrochemistry
  • Catalysis
  • Materials Science

Background:

  • Layered double hydroxides (LDHs) are effective electrocatalysts for oxygen evolution reaction (OER).
  • The chiral-induced spin selectivity (CISS) effect offers a new approach for spin-dependent catalysis.
  • Designing efficient and selective OER catalysts remains a significant challenge.

Purpose of the Study:

  • To investigate the impact of intercalating chiral phenylalanine molecules into CoFe-LDH on OER performance.
  • To explore the mechanism of chiral-induced spin selectivity in hybrid catalysts.
  • To establish a general strategy for developing advanced oxide-based electrocatalysts.

Main Methods:

  • Synthesis of chiral-inorganic hybrid catalysts by intercalating phenylalanine into CoFe-LDH.
  • Electrocatalytic testing for oxygen evolution reaction (OER) performance.
  • In situ XANES, in situ Raman spectroscopy, and nanoscale scanning electrochemical cell microscopy (SECCM) for mechanistic studies.

Main Results:

  • Intercalation of chiral phenylalanine induced spin-polarized OER via the CISS effect.
  • The chiral-inorganic hybrid catalyst exhibited a lower overpotential (245 mV at 10 mA cm⁻²) and faster charge-transfer kinetics compared to the achiral counterpart.
  • The chiral interface directed the reaction along a lower-energy pathway, promoting triplet O₂ formation.

Conclusions:

  • Chiral molecule intercalation in LDHs is a viable strategy to enhance OER performance through the CISS effect.
  • This approach offers a general route for designing advanced, stable oxide-based electrocatalysts by manipulating spin dynamics.
  • The study provides fundamental insights into chiral-induced spin-selective behavior in heterogeneous catalysis.