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Related Experiment Video

Updated: Jun 18, 2026

A Rat Model of Mild Intrauterine Hypoperfusion with Microcoil Stenosis
06:19

A Rat Model of Mild Intrauterine Hypoperfusion with Microcoil Stenosis

Published on: January 7, 2018

PLACENTAL AND FETAL RESPONSES TO ADRENOMEDULLIN DEFICIENCY IN THE RAT.

Marija Kuna1,2, Khursheed Iqbal1,2, Kelly Gorman3

  • 1Institute for Reproductive and Developmental Sciences.

Biology of Reproduction
|June 16, 2026
PubMed
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This summary is machine-generated.

Adrenomedullin (ADM) is crucial for fetal and placental development. ADM deficiency in rats leads to growth restriction, hemorrhage, and edema, causing embryonic lethality by late gestation.

Area of Science:

  • Reproductive biology
  • Developmental biology
  • Endocrinology

Background:

  • Adrenomedullin (ADM) is a peptide hormone with diverse cellular targets, including those at the uterine-placental interface.
  • The uterine-placental interface undergoes significant changes during pregnancy, making it a critical area for studying ADM's role.

Purpose of the Study:

  • To investigate the role of Adrenomedullin (ADM) in the development of the uterine-placental interface.
  • To generate and characterize an ADM-deficient rat model to study its in vivo effects.

Main Methods:

  • In situ hybridization was used to examine ADM expression patterns during gestation.
  • A germline ADM mutant rat model was created using CRISPR-Cas9 genome editing.
  • ADM heterozygous intercrosses were performed to assess the viability of ADM null offspring.
Keywords:
adrenomedullinfetal heartfetal lymphatic vesselsplacentatrophoblast cells

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Last Updated: Jun 18, 2026

A Rat Model of Mild Intrauterine Hypoperfusion with Microcoil Stenosis
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A Rat Model of Mild Intrauterine Hypoperfusion with Microcoil Stenosis

Published on: January 7, 2018

Fetal Mouse Cardiovascular Imaging Using a High-frequency Ultrasound (30/45MHZ) System
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Main Results:

  • ADM expression was observed in trophoblast giant cells and shifted to the mesometrial uterus during gestation.
  • ADM null rats were not viable past gestation day 15.5.
  • ADM deficiency resulted in fetal and placental growth restriction by gestation day 13.5, with hemorrhage and edema observed in null fetuses and placentas by gestation day 15.5.

Conclusions:

  • Adrenomedullin (ADM) is essential for normal placental and fetal development.
  • ADM plays a critical regulatory role in maintaining fetal and placental viability throughout gestation.