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Related Concept Videos

Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell types that...
Mesenchymal Stem Cells01:19

Mesenchymal Stem Cells

Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their access...
Source And Potency Of Stem Cells01:27

Source And Potency Of Stem Cells

Stem cells are undifferentiated cells with extensive self-renewal properties that help them maintain their population during the fetal and adult stages of life. They can specialize in all cell types of the human body. However, their differential potential may vary and can be classified into five types. Stem cells can be (1) Totipotent, (2) Pluripotent, (3) Multipotent, (4) Oligopotent, and (5) Unipotent. Each stem cell has a specific origin; the fertilized egg or zygote is a totipotent cell and...

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Updated: Jun 18, 2026

Microfluidic Fabrication of Core-Shell Microcapsules carrying Human Pluripotent Stem Cell Spheroids
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Microfluidic Fabrication of Core-Shell Microcapsules carrying Human Pluripotent Stem Cell Spheroids

Published on: October 13, 2021

Biodegradable Core-Shell Magnetic Microrobots With High Cell Capacity for Precise Co-Delivery of Stem Cells and

Tan Tang1, Han Gao2, Lanyu Xing1

  • 1School of Mechanical Engineering and Automation, Beihang University, Beijing, China.

Small (Weinheim an Der Bergstrasse, Germany)
|June 16, 2026
PubMed
Summary
This summary is machine-generated.

Biodegradable magnetic microrobots efficiently co-deliver stem cells and bioactive molecules for enhanced tissue regeneration. This novel platform shows promise for advancing regenerative medicine applications.

Keywords:
biomedical engineeringcartilageex vivomaterials sciencemesenchymal stem cellnanotechnologyregenerative medicinestem celltissue engineering

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Area of Science:

  • Biomaterials Engineering
  • Regenerative Medicine
  • Nanotechnology

Background:

  • Targeted delivery of stem cells and bioactive molecules is crucial for tissue regeneration.
  • Current methods face challenges in achieving high cell-loading capacity and effective co-delivery.
  • Developing multifunctional platforms is essential for improving therapeutic outcomes.

Purpose of the Study:

  • To develop a biodegradable magnetic microrobot for co-delivery of stem cells and bioactive molecules.
  • To enhance cell-loading capacity and ensure therapeutic viability of delivered cells.
  • To evaluate the efficacy of the microrobots in promoting cartilage repair and tissue regeneration.

Main Methods:

  • Fabrication of core-shell microrobots using rotation-induced inertial focusing.
  • Core composed of biodegradable magnetic microspheres (MMS) for navigation and drug release.
  • Shell formed by mesenchymal stem cells (MSCs) for therapeutic viability.
  • In vivo validation in rabbit models and ex vivo testing in human cartilage models.

Main Results:

  • Microrobots demonstrated controlled size and morphology with enhanced cell-loading capacity.
  • Robust magnetic maneuverability and spatial control were observed in complex environments.
  • Co-delivery of MSCs and transforming growth factor-β1 (TGF-β) significantly improved cartilage repair.
  • Successful validation in both in vivo and ex vivo models.

Conclusions:

  • Biodegradable core-shell magnetic microrobots offer a scalable platform for co-delivery.
  • This technology enhances stem cell and bioactive molecule delivery for tissue regeneration.
  • The microrobots show significant potential for clinical translation in regenerative medicine.