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The Inpatient Metastatic Spine Score: Prospective Validation on an Ongoing Multicenter Phase II Randomized Controlled

Shearwood McClelland1,2

  • 1Departments of Radiation Oncology.

American Journal of Clinical Oncology
|June 16, 2026
PubMed
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The Inpatient Metastatic Spine Score accurately predicts prognosis for patients with spinal metastases, achieving 72% accuracy. This score is significantly better than historical Medical Oncology prognosis for clinical trial enrollment.

Area of Science:

  • Oncology
  • Radiotherapy
  • Clinical Trials

Background:

  • Medical Oncology prognosis for spinal metastases has historically low accuracy (25%).
  • Accurate prognosis is crucial for patient management and clinical trial eligibility.

Purpose of the Study:

  • To evaluate the prognostic accuracy of the Inpatient Metastatic Spine Score.
  • To assess its utility for patient selection in the SPORTSMEN trial.

Main Methods:

  • Prospective evaluation of inpatients considered for the SPORTSMEN trial.
  • Prognosis assessed using the Inpatient Metastatic Spine Score (0-3 positive, 4-7 negative).
  • Statistical analysis using the Fisher test to compare score accuracy with actual prognosis.

Main Results:

Keywords:
inpatient metastatic spine scoreprognosisrandomized controlled trialspine metastases

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  • The Inpatient Metastatic Spine Score achieved 72% accuracy in predicting patient prognosis.
  • Patients with scores 0-3 had a 64% positive prognosis, versus 21% for scores 4-7 (P=0.0486).
  • This accuracy (72%) was significantly higher than the historical Medical Oncology prognosis (P=0.0351).

Conclusions:

  • The Inpatient Metastatic Spine Score demonstrates 72% accuracy in prognostic assessment for spinal metastases.
  • This score is significantly superior to historical Medical Oncology prognosis.
  • The Inpatient Metastatic Spine Score is recommended for determining prognosis in this patient population.