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Related Experiment Video

Updated: Jun 18, 2026

Development of an Antigen-driven Colitis Model to Study Presentation of Antigens by Antigen Presenting Cells to T Cells
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Published on: September 18, 2016

Development of a Digital Phenotype for Immune-Related Colitis.

Jasmine C Teng1,2, Leon J Worth1,2, Karin A Thursky1,3

  • 1National Centre for Infections in Cancer, Peter MacCallum Cancer Centre, Parkville, Australia.

JCO Clinical Cancer Informatics
|June 16, 2026
PubMed
Summary

A new digital phenotype accurately identifies immune-related colitis (IR-colitis) in patients receiving immune checkpoint inhibitors (ICIs). This EMR-based tool enables rapid case detection for improved patient outcomes and research.

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Last Updated: Jun 18, 2026

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Area of Science:

  • Oncology
  • Immunology
  • Health Informatics

Background:

  • Immune checkpoint inhibitors (ICIs) are crucial cancer therapies.
  • Immune-related colitis (IR-colitis) is a common and serious side effect.
  • Early detection of IR-colitis is vital for patient management.

Purpose of the Study:

  • To develop an electronic medical record (EMR)-based digital phenotype for identifying IR-colitis.
  • To create a resource-efficient method for retrospective case detection.

Main Methods:

  • A rule-based digital phenotype was created using expert-selected features from EMR data.
  • The study included adult patients treated with ICIs between August 2020 and June 2023.
  • Manual chart review served as the gold standard for validation.

Main Results:

  • The developed digital phenotype demonstrated high performance metrics.
  • Key performance indicators included 80% sensitivity and 97% specificity.
  • Accuracy was 89%, with a positive predictive value of 74% and negative predictive value of 98%.

Conclusions:

  • An accurate EMR-based digital phenotype for IR-colitis was successfully developed.
  • This tool facilitates rapid and precise identification of IR-colitis cases.
  • The phenotype can support real-world adverse event surveillance and biomarker research.